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Hongotoxin-1

Cat no: RTH-400

Hongotoxin-1

Hongotoxin-1. A Potent Blocker of Some Kv1 K+пїЅChannels.
Hongotoxin was originally isolated from the scorpion Centruroides limbatus and was shown to block cloned and heterologously expressed (in HEK 293 cells) Kv1.1, 1.2 and 1.3 with IC50 of 31, 170 and 86 pM respectively. In addition, it blocks Kv1.6 with low affinity (IC50 = 6nM). Hongotoxin-1 action was examined by monitoring radiolabeled Rb+ efflux from Kv channels-transfected HEK 293 cells. Hongotoxin-1 blocks 125I-Margtoxin (Margatoxin) binding to rat brain synaptosomes or 125I-Kaliotoxin binding to purified Kv1.3-KcsA chimeras. A mutated 125I-Hongotoxin-1 was used to immunoprecipitate (with specific Kv antibodies) rat brain Kv channels and to determine their subunit composition.
Ion Channel Modulators; K+ Channel Blockers.

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SPECIFICATIONS

Catalog Number

RTH-400

Size

0.1 mg

Purity

>98%

Concentration

0.1-0.2 pM.

Shipping Temp

Room Temperature

Molecular Weight

4220 da

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