HOXA9 (Homeobox Protein Hox-A9, Homeobox Protein Hox-1G, HOX1G)

Homeobox protein A9 (HOXA9) is a protein that in humans is encoded by the HOXA9 gene. In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is highly similar to the abdominal-B (Abd-B) gene of Drosophila. A specific translocation event which causes a fusion between this gene and the NUP98 gene has been associated with myeloid leukemogenesis. Transfection studies showed that HOXA9 is a strong transcriptional repressor; it suppresses the transcription of the luciferase reporter gene driven by a 124-base pair OPN promoter fragment containing both Smad3 and HOX binding sites.\n\nApplications:\nSuitable for use in Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nImmunohistochemistry (formalin fixed paraffin embedded): 5ug/ml\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

H7022-90A

Size

100ug

Applications

IHC

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat, Can, Ch/Bird

Form

Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.

P Type

Pab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG

References

1. Izon, D. J. et al. Blood 92:383-393 (1998). 2. Shi, X. et al. J. Biol. Chem. 276:850-855 (2001).

Additional Info

Recognizes human HOXA9. Species Crossreactivity: chicken, chimpanzee, canine, mouse, rat, rhesus monkey. Species sequence homology: elephant shark, zebrafish.