HPV E6, Recombinant, Viral (HpV16gp1, HPV Early Protein 6, Papillomavirus E6)

Supplier:

United States Biological

Cat no: 145802

HPV E6, Recombinant, Viral (HpV16gp1, HPV Early Protein 6, Papillomavirus E6)

E6 (Early protein 6) is a viral protein produced in cells infected with the Human Papillomavirus. E6 forms a complex with the host cell ubiquitin ligase E6AP (E6-Associated-Protein) generating a ligase activity that polyubiquitinates tumor suppressors p53 and p73 and targets them to the 26S proteasome for degradation. As a result DNA damage and chromosomal instabilities increase, often leading to cell proliferation and cancer. The E6/E6AP complex also targets other substrates for ubiquitination, such as TERT, BAK1, FADD, and pro-CASP8

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SPECIFICATIONS

Catalog Number

145802

Size

25ug

Form

Supplied as a liquid in 50mM Hepes, pH 7.0, 400mM NaCl, 2mM DTT. BSA free.

Purity

~90% (SDS-PAGE)

References

1. Beaudenon S. & Huibregtse J.M. (2008) BMC Biochem. 9 (Supp1):S4. 2. Zanier K., et al. (2007) Prot. Exp. & Purif. 51:59-70. 3. Zanier K., et al. (2010) J. Mol. Biol. 396: 90-104.

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SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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