HRX, CT (ALL-1, Trithorax-like Protein, Histone-lysine N-methyltransferase MLL, Zinc Finger Protein HRX, Lysine N-methyltransferase 2A, KMT2A, CXXC-type Zinc Finger Protein 7, MLL, CXXC7, HTRX, MLL1, TRX1) (FITC)

The gene variously symbolized ALL1, HRX, or MLL located on 11q23 has been demonstrated to be fused with a number of translocation partners in cases of leukemia. Tse et al. (1995) characterized 2 t(1;11)(q21;q23) translocations that fused the MLL gene to a gene on chromosomal band 1q21, AF1Q, in 2 infants with acute myelomonocytic leukemia. In one of these patients, the derivative chromosome 11 represented an in-frame fusion of the N-terminal portion of the MLL gene to the complete AF1Q open reading frame, whereas the derivative chromosome 1 did not give rise to an open reading frame. This observation suggested that the N-terminal portion of the MLL gene is critical for leukemogenesis in translocations involving band 11q23.\n\nApplications: \nSuitable for use in ELISA, Western Blot, and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:1,000\nWestern Blot: 1:100-1:500\nImmunohistochemistry: 1:50-1:100\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Do not freeze FITC conjugates. Light sensitive. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

M4127-01A-FITC

Size

200ul

Applications

ELISA, IHC, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to FITC.

P Type

Pab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG

References

1.Megonigal, M.D., et al., Proc. Natl. Acad. Sci. USA 97(6):2814-2819 (2000). 2.Pegram, L.D., et al., Blood 96(13):4360-4362 (2000). 3.Sano, K., et al., Blood 95(3):1066-1068 (2000). 4.Cui, X., et al., Nat. Genet. 18(4):331-337 (1998). 5.Nilson, I., et al., Br. J. Haematol. 93(4):966-972 (1996).

Additional Info

Recognizes human HRX.