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HSD11B1 Peptide

HSD11B1 Peptide

Cat no: BS5588P

Supplier: Bioworld Technology, Inc.
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Glucocorticoid hormone action in target tissues is modulated by 11b-hydroxysteroid dehydrogenase (11b-HSD), which catalyzes the interconversion of hormonally active C11-hydroxylated corticosteroids (cortisol, corticosterone) and their inactive C11-keto metabolites (cortisone, 11-dehydrocorticosterone). At least two isoforms of 11b-HSD exist: a low-affinity NADP-dependent dehydrogenase/oxoreductase (11b-HSD1) and a high-affinity NAD-dependent dehydrogenase (11b-HSD2). The glycosylated 11b-HSD1 protein activates cortisol from cortisone, which is widely expressed in mammals, and is most highly expressed in the liver. 11b-HSD1 may play a role in glucose homeostasis and pathogenesis of a number of disorders including insulin resistance and obesity.
Catalogue number: BS5588P
Applications: Block/Neutralize/Inhibit
Swiss prot: P28845
Form: 1 mg/ml in DI water.
Purity: Synthetic peptide HSD11B1. (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names: Corticosteroid 11-beta-dehydrogenase isozyme 1; 11-beta-hydroxysteroid dehydrogenase 1; 11-DH; 11-beta-HSD1; HSD11B1; HSD11; HSD11L; 11beta-HSD1; 11beta HSD1; 11betaHSD1
Additional info: This peptide can be used with studies using BS5588 HSD11B1 pAb.

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