HSP70 (HSPA1, Hsp70-1, Hsp70-2, Heat shock 70kD protein 1/2)

Heat-shock proteins, or stress proteins, are expressed in response to heat shock and a variety of other stress stimuli including oxidative free radicals and toxic metal ions. Sargent et al. (1989) identified a duplicated HSP70 locus in the class III region of the major histocompatibility complex on 6p21.3. A duplicated locus encoding the major heat shock-induced protein HSP70 is located in the major histocompatibility complex (MHC) class III region 92 kilobases (kb) telomeric to the C2 gene. The 70-kd mammalian heat shock proteins are structurally and functionally related to the uncoating protein that releases clathrin triskelia from coated vesicles.\n\nUniProt Number:\nHuman(P08107), Mouse(Q61696), Rat(Q07439), Mouse(P17879)\n\nGene ID:\nHSPA1A; HSPA1B\n\nApplications:\nSuitable for use in Western Blot, Immunohistochemistry (Paraffin and Frozen).\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Handling:\nStore at -20?C for one year. After reconstitution, store at 4?C for one month. Can also be aliquoted and stored frozen at -20?C for long term.\nAvoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

144695

Size

100ug

Applications

IHC, WB

Hosts

Mouse

Reactivities

Hum, Rat, Bov, Rabbit

Form

Ascites, supplied as a lyophilized powder. Reconstitution: 1.2% sodium acetate or neutral PBS. If 1ml of PBS is used, the antibody concentration will be 100ug/ml.

P Type

Mab

Isotype

IgG1

References

1. Milner, C. M.; Campbell, R. D. : Structure and expression of the three MHC-linked HSP70 genes. Immunogenetics 32: 242-251, 1990.\n2. Ungewickell, E. : The 70-kd mammalian heat shock proteins are structurally and functionally related to the uncoating protein that releases clathrin triskelia from coated vesicles. EMBO J. 4: 3385-3391, 1985.

Additional Info

Recognizes human, rat, bovine and rabbit HSP70. No cross reactivity with other proteins.