HTR2C, ID (HTR2C, HTR1C, 5-hydroxytryptamine receptor 2C, 5-hydroxytryptamine receptor 1C, Serotonin receptor 2C) (AP)

Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in humans have reported abnormalities in patterns of 5-HT2C editing in depressed suicide victims.\n\nApplications:\nSuitable for use in Western Blot, ELISA\n\nRecommended Dilution:\nELISA: 1:1,000\nWestern Blot: 1:100-500\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Do not freeze alkaline phosphatase conjugates which could result in a substantial loss of enzymatic activity. Light sensitive. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

036826-AP

Size

200ul

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to Alkaline Phosphatase.

P Type

Pab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG

References

Gregoor, J.G., et al. Psychiatr. Genet. 20(6):311-316(2010)\nBailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)\nKiezebrink, K., et al. World J. Biol. Psychiatry 11(6):824-833(2010)\nRisselada, A.J., et al. Pharmacogenomics J. (2010) In press :\nMcGrew, L., et al. Mol. Pharmacol. 65(1):252-256(2004)

Additional Info

Human

Alternative Names

HTR2C, HTR1C, 5-hydroxytryptamine receptor 2C, 5-hydroxytryptamine receptor 1C, Serotonin receptor 2C