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Human A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) ELISA Kit

Human A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) ELISA Kit

Cat no: KTE60921

Supplier: Abbkine Scientific Co.Ltd.
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ADAMTS5 is a member of the ADAMTS protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage. Genetically modified mice in which the catalytic domain of ADAMTS5 was deleted are resistant to cartilage destruction in an experimental model of osteoarthritis.ADAMTS5 is the major aggrecanase in mouse cartilage in a mouse model of inflammatory arthritis.
Catalogue number: KTE60921
Reactivities: Human
Applications: ELISA
Size: 48T, 96T, 96T*5, 96T*50
Accession: Q9TT92
Additional info: Human A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) ELISA Kit has high sensitivity and excellent specificity for detection of Human ADAMTS5. No significant cross-reactivity or interference between Human ADAMTS5 and analogues was observed.

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