Human Alpha-actinin-4 (ACTN-4) ELISA Kit

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments.\nAlpha-actinin-4 is a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis.

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SPECIFICATIONS

Catalog Number

KTE60901

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

81

Accession

O43707

Additional Info

Human Alpha-actinin-4 (ACTN-4) ELISA Kit has high sensitivity and excellent specificity for detection of Human ACTN4. No significant cross-reactivity or interference between Human ACTN4 and analogues was observed.