Human Aspartyl/asparaginyl beta-hydroxylase (ASPH) ELISA Kit

ASPH is is thought to play an important role in calcium homeostasis. The gene is expressed from two promoters and undergoes extensive alternative splicing. The encoded set of proteins share varying amounts of overlap near their N-termini but have substantial variations in their C-terminal domains resulting in distinct functional properties. The longest isoforms (a and f) include a C-terminal Aspartyl/Asparaginyl beta-hydroxylase domain that hydroxylates aspartic acid or asparagine residues in the epidermal growth factor (EGF)-like domains of some proteins, including protein C, coagulation factors VII, IX, and X, and the complement factors C1R and C1S. Other isoforms differ primarily in the C-terminal sequence and lack the hydroxylase domain, and some have been localized to the endoplasmic and sarcoplasmic reticulum.

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SPECIFICATIONS

Catalog Number

KTE62438

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

444

Accession

Q12797

Additional Info

Human Aspartyl/asparaginyl beta-hydroxylase (ASPH) ELISA Kit has high sensitivity and excellent specificity for detection of Human ASPH. No significant cross-reactivity or interference between Human ASPH and analogues was observed.