Human ATP-binding cassette sub-family C member 8 (ABCC8) ELISA Kit

ABCC8 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion.

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SPECIFICATIONS

Catalog Number

KTE60863

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

6833

Accession

Q09428

Additional Info

Human ATP-binding cassette sub-family C member 8 (ABCC8) ELISA Kit has high sensitivity and excellent specificity for detection of Human ABCC8. No significant cross-reactivity or interference between Human ABCC8 and analogues was observed.