Human ATP-dependent zinc metalloprotease YME1L1 (YME1L1) ELISA Kit

YME1L1 is the human ortholog of yeast mitochondrial AAA metalloprotease, Yme1p. It is localized in the mitochondria and can functionally complement a yme1 disruptant yeast strain. It is proposed that this gene plays a role in mitochondrial protein metabolism and could be involved in mitochondrial pathologies. Two transcript variants encoding different isoforms have been found for this gene.\nYME1L1 shares 50% sequence identity with yeast Yme1, 40% identity with yeast Rca1, and 39% identity with yeast Afg3, with highest homology in the central regions of the proteins. Northern blot analysis revealed transcripts of about 2.6 and 4.4 kb in all tissues examined, with greatest abundance in adult heart, skeletal muscle, and pancreas.

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SPECIFICATIONS

Catalog Number

KTE60008

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

10730

Accession

Q96TA2

Additional Info

Human ATP-dependent zinc metalloprotease YME1L1 (YME1L1) ELISA Kit has high sensitivity and excellent specificity for detection of Human YME1L1. No significant cross-reactivity or interference between Human YME1L1 and analogues was observed.