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Human Cardiac phospholamban (PLN) ELISA Kit

Human Cardiac phospholamban (PLN) ELISA Kit

Cat no: KTE61205

Supplier: Abbkine Scientific Co.Ltd.
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Phospholamban is a 52 amino acid integral membrane protein that regulates the Ca2 pump in cardiac muscle and skeletal muscle cells. When phospholamban is phosphorylated by protein kinase A (PKA) its ability to to inhibit the sarcoplasmic reticulum calcium pump (SERCA) is lost. Thus, activators of PKA, such as the beta-adrenergic agonist epinephrine (released by sympathetic stimulation) may enhance the rate of cardiac myocyte relaxation. Additionally, since SERCA is more active, the next action potential will cause an increased release of calcium resulting in increased contraction (positive inotropic effect). When phospholamban is not phosphorylated, such as when PKA is inactive, it can interact with and inhibit SERCA.
Catalogue number: KTE61205
Reactivities: Human
Applications: ELISA
Size: 48T, 96T, 96T*5, 96T*50
Accession: P26678
Gene: 5350
Additional info: Human Cardiac phospholamban (PLN) ELISA Kit has high sensitivity and excellent specificity for detection of Human PLN. No significant cross-reactivity or interference between Human PLN and analogues was observed.

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