Human CC-Chemokine Receptor 5 (CCR5) ELISA Kit

CCR5 is a member of the beta chemokine receptors family of integral membrane proteins.In Humans, the CCR5 gene location is on the short (p) arm at position 21 on chromosome 3. Certain populations have inherited theВ Delta 32В mutation resulting in the Genetic deletion of the CCR5 gene. Homozygous carriers of this mutation are resistant to HIV-1 infection. The CCR5 protein is a seven transmembrane protein which functions as a chemokine receptor in the CC chemokine group. The natural chemokine ligands that bind to this receptor are RANTES, MIP-1?В and MIP-1?. CCR5 is predominantly expressed on T cells, macrophages, dendritic cells and microglia. It is likely that CCR5 plays a role in inflammatory responses to infection, though its exact role in normal immune function is unclear.

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SPECIFICATIONS

Catalog Number

KTE62546

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

497017

Accession

Q2HJ17

Additional Info

Human CC-Chemokine Receptor 5 (CCR5) ELISA Kit has high sensitivity and excellent specificity for detection of Human CCR5. No significant cross-reactivity or interference between Human CCR5 and analogues was observed.