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human CNTF

Cat no: C-240

human CNTF

CNTF is a polypeptide trophic factor, member of the alpha-helical cytokine superfamily.
It was initially purified from the chick eye on the basis of its ability toпїЅpromote survival of E8 chick ciliary ganglion neurons in culture.пїЅCNTF is synthesized by glia both in the CNS and PNS and it has been demonstratedпїЅthat CNTF is ubiquitously distributed in neurons and glia throughoutпїЅthe rodent brain.
CNTF effects are mediated by a tripartite receptor complex consisting of two signal-transducing subunits (leukemia inhibitory factor receptor, gp130) and a CNTF-specific ligand-binding-subunit (CNTFR).

пїЅCNTF can support the survival of many different cell populations within the PNS and the CNS.
in vitro, CNTF promotes proliferation and neuronal specificationsпїЅin hippocampal neurons.
in vivo, it supports the viability of non-primate motor neurons, CNTF induces sprouting of cholinergicпїЅmotor neurons and delays neural degeneration in genetic modelsпїЅof motor neuron disease.
In addition, it is involved in the development stage of astrocytes and oligodendocytes.

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SPECIFICATIONS

Catalog Number

C-240

Size

5 x 5 micro g

Purity

>98%

Concentration

1 nM

Shipping Temp

Room Temperature

Molecular Weight

22.9 kDa

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