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Human CUGBP Elav-like family member 3 (TNRC4) ELISA Kit

Human CUGBP Elav-like family member 3 (TNRC4) ELISA Kit

Cat no: KTE60178

Supplier: Abbkine Scientific Co.Ltd.
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CELF proteins, including CELF3, bound RNA containing muscle-specific splicing enhancer (MSE) elements and could activate MSE-dependent exon inclusion of cardiac troponin T (TNNT2) minigenes in transfected quail fibroblasts.The deduced 462-amino acid protein contains 2 N-terminal RNA recognition motifs (RRMs), a C-terminal RRM, several potential phosphorylation sites, and a nuclear localization signal near the C terminus. activated inclusion of exon 10 in a tau (MAPT) minigene. Deletion and mutation analyses showed that the activity of TNRC4 on tau exon 10 splicing required RRM2 in TNRC4 and an intronic element in tau pre-mRNA. The polyglutamine sequence of TNRC4 had no effect on tau exon 10 splicing. Tnrc4 -/- mice exhibited decreased inclusion of exon 10 in tau mRNA.
Catalogue number: KTE60178
Reactivities: Human
Applications: ELISA
Size: 48T, 96T, 96T*5, 96T*50
Accession: Q5SZQ8
Gene: 11189
Additional info: Human CUGBP Elav-like family member 3 (TNRC4) ELISA Kit has high sensitivity and excellent specificity for detection of Human TNRC4. No significant cross-reactivity or interference between Human TNRC4 and analogues was observed.

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