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Human Dynorphin (DYN) ELISA Kit

Human Dynorphin (DYN) ELISA Kit

Cat no: KTE62647

Supplier: Abbkine Scientific Co.Ltd.
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Big dynorphin (Big Dyn), a 32-amino acid prodynorphin-derived peptide consisting of Dyn A and Dyn B, with human KOR, mu- (hMOR) and delta- (hDOR) opioid receptors and opioid receptor-like receptor 1 (hORL1) expressed in cells transfected with respective cDNA. Big Dyn and Dyn A demonstrated roughly similar affinity for binding to hKOR that was higher than that of Dyn B. Big Dyn activated G proteins through KOR with much greater potency, efficacy and selectivity than other dynorphins.  Immunoreactive Big Dyn was detected using the combination of radioimmunoassay (RIA) and HPLC in the human nucleus accumbens, caudate nucleus, hippocampus and cerebrospinal fluid (CSF) with the ratio of Big Dyn and Dyn B being approximately 1:3. The presence in the brain implies that Big Dyn, along with other dynorphins, is processed from prodynorphin and secreted from neurons.
Catalogue number: KTE62647
Reactivities: Human
Applications: ELISA
Size: 48T, 96T, 96T*5, 96T*50
Additional info: Human Dynorphin (DYN) ELISA Kit has high sensitivity and excellent specificity for detection of Human Dyn. No significant cross-reactivity or interference between Human Dyn and analogues was observed.

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