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Human E3 ubiquitin-protein ligase CHIP (STUB1) ELISA Kit

Cat no: KTE60397


Supplier: Abbkine Scientific Co.Ltd.
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The CHIP protein encoded by this gene binds to and inhibits the ATPase activity of the chaperone proteins HSC70 and HSP70 and blocks the forward reaction of the HSC70-HSP70 substrate-binding cycle. In addition, CHIP possesses E3 ubiquitin ligase activity and promotes ubiquitylation. CHIP enhances HSP70 induction during acute stress and also mediates its turnover during the stress recovery process. The deduced 303-amino acid proteinhas a molecular mass of 35 kD and contains three 34-amino acid TPR domains at its N terminus, a central domain rich in charged residues, and 2 potential nuclear localization signals. Human CHIP shares 97% and 53% amino acid identity with its mouse and Drosophila homologs, respectively, with the highest conservation in the 94 residues of the C terminus.
Catalogue number: KTE60397
Reactivities: Human
Applications: ELISA
Size: 48T, 96T, 96T*5, 96T*50
Accession: Q9UNE7
Gene: 10273
Additional info: Human E3 ubiquitin-protein ligase CHIP (STUB1) ELISA Kit has high sensitivity and excellent specificity for detection of Human STUB1. No significant cross-reactivity or interference between Human STUB1 and analogues was observed.

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