Human E3 ubiquitin-protein ligase UBR1 (UBR1) ELISA Kit

The mouse Ubr1 protein is a 1,757-residue, 200-kD protein that contains regions with sequence similarity to the 225-kD UBR1 protein of S. cerevisiae. There are apparent UBR1 homologs in other eukaryotes, thus defining a distinct family of proteins, the UBR family. The residues essential for substrate recognition by the yeast UBR1 protein are conserved in the mouse Ubr1 protein. Regions of similarity among the UBR family members include a putative zinc finger and RING-H2 finger, another zinc-binding domain. Northern blot analysis detected ubiquitous expression in human and adult mouse tissues, with highest levels in skeletal muscle and heart. In mouse embryos, in situ hybridization showed that Ubr1 expression is highest in the branchial arches and in the tail and limb buds.

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SPECIFICATIONS

Catalog Number

KTE60095

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

197131

Accession

Q8IWV7

Additional Info

Human E3 ubiquitin-protein ligase UBR1 (UBR1) ELISA Kit has high sensitivity and excellent specificity for detection of Human UBR1. No significant cross-reactivity or interference between Human UBR1 and analogues was observed.