Human Glucose transporter 4 (GLUT4) ELISA Kit

GLUT4 is the insulin-regulated glucose transporter found in adipose tissues and striated muscle (skeletal and cardiac) that is responsible for insulin-regulated glucose disposal.In the absence of insulin, GLUT4 is sequestered in the interior of muscle and fat cells within lipid bilayers of vesicles. Insulin induces the translocation of GLUT4 from intracellular storage sites to the plasma membrane. Insulin binds to the insulin receptor in its dimeric form.\nThe receptor phosphorylates and subsequently activates IRS-1, which converts PIP2 to PIP3. PIP3 is bound to PKB (protein kinase B), signaling for PDK1 to phosphorylate PKB. Once phosphorylated, PKB is in its active form and phosphorylates other targets that stimulate GLUT4 to be expressed on the plasma membrane.

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SPECIFICATIONS

Catalog Number

KTE60607

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

6517

Accession

P14672

Additional Info

Human Glucose transporter 4 (GLUT4) ELISA Kit has high sensitivity and excellent specificity for detection of Human SLC2A4. No significant cross-reactivity or interference between Human SLC2A4 and analogues was observed.