The dermal papilla is a highly active group of cells. It is derived from the dermis mesenchyme, located at the base of the hair follicle. The dermal papilla is implicated in controlling the hair growth cycle; dermal papilla cells are capable of inducing follicle development from the epidermis and the production of hair fiber. Early passage dermal papilla cells can induce hair growth in vivo, but, upon further culturing, this property is lost. Hair growth is tightly regulated by the epithelial-mesenchymal interaction of hair follicle cells, for example, interferon beta secreted from dermal papilla cells inhibits the growth of outer root sheath cells in cultured. The survival of dermal papilla cell is also regulated by signal transduction pathways, activating both ERK and Akt promote dermal papilla cell survival.
HHDPC are isolated from dermal papilla of human hair follicles. HHDPC are cryopreserved at passage one culture and delivered frozen. Each vial contains >5 x 10^5 cells in 1 ml volume. HHDPC are characterized by their mesenchymal cell morphology and immunofluorescent method with antibody to fibronectin and CD105. HHDPC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HHDPC are guaranteed to further expand for 15 population doublings at the condition provided by Creative Bioarray.
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