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Human Heterogeneous nuclear ribonucleoprotein I (hnRNP I/PTB) ELISA Kit

Human Heterogeneous nuclear ribonucleoprotein I (hnRNP I/PTB) ELISA Kit

Cat no: KTE61076

Supplier: Abbkine Scientific Co.Ltd.
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hnRNP I/PTB belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. Heterogeneous nuclear ribonucleoprotein I encoded by hnRNP I/PTB has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. Heterogeneous nuclear ribonucleoprotein I is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.
Catalogue number: KTE61076
Reactivities: Human
Applications: ELISA
Size: 48T, 96T, 96T*5, 96T*50
Accession: P26599
Gene: 5725
Additional info: Human Heterogeneous nuclear ribonucleoprotein I (hnRNP I/PTB) ELISA Kit has high sensitivity and excellent specificity for detection of Human PTBP1. No significant cross-reactivity or interference between Human PTBP1 and analogues was observed.

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