Creative Bioarray's Pooled Human Liver S9 Fractions provide a fully characterized, relevant, reliable and reproducible in vitro tool. Pooled Liver S9 Fractions from pools of 50 donors gives an accurate and economic method of deriving a population representation that may be sed to describe the metabolic profile of a drug or drug candidate in high-throughput assays as well as the following other uses:
Conduct studies of metabolic stability (% of original drug remaining over time)
Identify which cytochrome P450 (CYP) enzymes oxidize a drug candidate and which UDP-glucuronosyltransferase (UGT) enzymes are responsible for glucuronidation
Identify, quantify and characterize drug metabolites
Describe a drug's metabolic pathways
Identify inhibition of cytochrome P450 (CYP) enzymes
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