Human NAD-dependent deacetylase sirtuin-3, mitochondrial (SIRT3) ELISA Kit

SIRT3 is a soluble protein located in the mitochondrial matrix, and contains a mitochondrial processing peptide at the N-terminus. A set of crystal structures of human SIRT3 have been solved, including an apo-structure with no substrate, a structure with a peptide containing acetyl lysine of its natural substrate acetyl-CoA synthetase 2, a reaction intermediate structure trapped by a thioacetyl peptide and a structure with the dethioacetylated peptide bound. These structures show the conformational changes induced by the two substrates required for the reaction, the acetylated substrate peptide and NAD+. In addition, a binding study by isothermal titration calorimetry suggests that the acetylated peptide is the first substrate to bind to SIRT3, prior to NAD+.

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SPECIFICATIONS

Catalog Number

KTE60652

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

23410

Accession

Q9NTG7

Additional Info

Human NAD-dependent deacetylase sirtuin-3, mitochondrial (SIRT3) ELISA Kit has high sensitivity and excellent specificity for detection of Human SIRT3. No significant cross-reactivity or interference between Human SIRT3 and analogues was observed.