Human Nicotinate-nucleotide pyrophosphorylase (QPRT) ELISA Kit

Cat no: KTE61003

Supplier: Abbkine Scientific Co.Ltd.

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Quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan and acts as a potent endogenous excitotoxin through hyperstimulation of N-methyl D-aspartate (NMDA) receptor in the neuron. Elevation of quinolinate levels in the human brain has been postulated to be involved in the pathogenesis of neurodegenerative disorders. Mammalian quinolinate phosphoribosyltransferase (QPRTase) is a key enzyme in catabolism of quinolinate.This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease.

Catalogue number:	KTE61003
Reactivities:	Human
Applications:	ELISA
Size:	48T, 96T, 96T5, 96T50
Accession:	Q15274
Gene:	23475
Additional info:	Human Nicotinate-nucleotide pyrophosphorylase (QPRT) ELISA Kit has high sensitivity and excellent specificity for detection of Human QPRT. No significant cross-reactivity or interference between Human QPRT and analogues was observed.

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Human Nicotinate-nucleotide pyrophosphorylase (QPRT) ELISA Kit

Cat no: KTE61003

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