Human Orexigenic neuropeptide QRFP (QRFP) ELISA Kit

P518 functions as a high-affinity ligand of GPR103. Both GPR103 and P518 precursor mRNA exhibited highest expression in brain.The 43-amino acid QRFP peptide, a longer form of the P518 peptide is necessary to exhibit full agonistic activity with GPR103. Intravenous administration QRFP caused release of aldosterone, suggesting that QRFP and GPR103 regulate adrenal function.The deduced 126-amino acid protein contains a putative N-terminal 22-amino acid signal peptide and no transmembrane domain, suggesting that the protein or cleavage products can be secreted. The 26-amino acid P518 peptide sequence is located at the C terminus of the precursor protein. In peripheral tissues, P518 precursor mRNA was detected in prostate, testis, colon, thyroid, parathyroid, coronary artery, and bladder.

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SPECIFICATIONS

Catalog Number

KTE61002

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

347148

Accession

P83859

Additional Info

Human Orexigenic neuropeptide QRFP (QRFP) ELISA Kit has high sensitivity and excellent specificity for detection of Human QRFP. No significant cross-reactivity or interference between Human QRFP and analogues was observed.