Human P16 (5A8A) Antibody

Cat no: 252710

Supplier: ABBIOTEC

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Description
Additional Information

CDK4I or p16-INK4 (Cyclin-dependent kinase 4 inhibitor A) is a negative regulator of the proliferation of normal cells. It is interacting strongly with CDK4 and CDK6 and by subsequently inhibiting their interaction with cyclins D and retinoblastoma protein phosphorylation. Defects in p16-INK4 are involved in tumor formation in a wide range of tissues. These defects cause cutaneous malignant melanoma 2 (CMM2), familial atypical multiple mole melanoma-pancreatic carcinoma syndrome,Mouse,elanoma-astrocytoma syndrome and Li-Fraumeni syndrome.

Catalogue number:	252710
Reactivities:	Human
Applications:	Immunohistochemistry
Size:	0.1 mg
Accession:	P42771
Antigen:	Purified recombinant fragment of P16 e, Xenopus/Amphibian,pressed in E. coli.
Format:	Each vial contains 0.1 mg IgG in PBS pH7.4 with 0.03% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type:	Mouse Monoclonal Antibody
Isotype:	Mouse IgG1
Clonality:	5A8A4,3G8D12
Additional info:	Human P16; P16; Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3; cyclin-dependent kinase inhibitor A; CDK4I; p16-INK4a; p16INK4A; p16-INK4; multiple tumor suppressor 1; MTS-1; CDKN2A; CDKN2; MTS1