Human Perforin-1 (PRF1/PFP) ELISA Kit

Perforin is a cytolytic protein found in the granules of CD8 T-cells and NK cells. Perforin is a cytolytic protein found in the granules of Cytotoxic T lymphocytes (CTLs) and NK cells. Upon degranulation, perforin inserts itself into the target cell's plasma membrane, forming a pore. The lytic membrane-inserting part of perforin is the MACPF domain. This region shares homology with cholesterol-dependent cytolysins from Gram-positive bacteria. Perforin has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis.

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SPECIFICATIONS

Catalog Number

KTE61168

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

5551

Accession

P14222

Additional Info

Human Perforin-1 (PRF1/PFP) ELISA Kit has high sensitivity and excellent specificity for detection of Human PRF1. No significant cross-reactivity or interference between Human PRF1 and analogues was observed.