Human Plasma protease C1 inhibitor (SERPING1) ELISA Kit

C1-INH is a critically important protein that controls activation of multiple plasma mediator pathways. This protein, a member of the serine protease inhibitor (serpin) group, originally was described as an inhibitor of C1. It binds stoichiometrically to the active sites on both C1r and C1s to form a complex C1-INH-C1r-C1s-C1-INH and thus inhibits activated C1. In addition, C1-INH has been reported to remove the intact C1qrs complex from an activating surface and to inhibit autoactivation of C1. C1-INH is a known inhibitor of kinin generating (kallikrein), fibrinolytic (plasmin), and contact activation (intrinsic) pathway of the coagulation cascade. Recently, it has been shown to be an inhibitor of the mannan-binding lectin pathway of complement activation, inhibiting mannan-binding lectin-associated serine proteases (MASPs) in that pathway.

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SPECIFICATIONS

Catalog Number

KTE60690

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

710

Accession

P05155

Additional Info

Human Plasma protease C1 inhibitor (SERPING1) ELISA Kit has high sensitivity and excellent specificity for detection of Human SERPING1. No significant cross-reactivity or interference between Human SERPING1 and analogues was observed.