Human Platelet-derived growth factor subunit B (PDGFB) ELISA Kit

Platelet-derived growth factor subunit B is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two splice variants have been identified for this gene.

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SPECIFICATIONS

Catalog Number

KTE61271

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Additional Info

Human Platelet-derived growth factor subunit B (PDGFB) ELISA Kit has high sensitivity and excellent specificity for detection of Human PDGFB. No significant cross-reactivity or interference between Human PDGFB and analogues was observed.