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Human Proinsulin (PI) ELISA Kit

Human Proinsulin (PI) ELISA Kit

Cat no: KTE61220

Supplier: Abbkine Scientific Co.Ltd.
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Proinsulin is synthesized in the pancreatic beta cells as a 9390 mw polypeptide of 86 amino acids. Proinsulin is subsequently cleaved enzymatically, releasing insulin into the circulation along with a residual 3000 mw fragment called C-peptide, so-named because it connects the A and B chains of insulin within the proinsulin molecule. Proinsulin, which has relatively low biological activity (approximately 10% of insulin potency), is the major storage form of insulin. Normally, only small amounts (~3% of the amount of insulin, on a molar basis) of proinsulin enter the circulation. Because the hepatic clearance of proinsulin is only 25% of insulin clearance, the half-life of proinsulin is two- to threefold longer and concentrations in the fasting state are approximately 10% to 15% of insulin concentrations.
Catalogue number: KTE61220
Reactivities: Human
Applications: ELISA
Size: 48T, 96T, 96T*5, 96T*50
Additional info: Human Proinsulin (PI) ELISA Kit has high sensitivity and excellent specificity for detection of Human PI. No significant cross-reactivity or interference between Human PI and analogues was observed.

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