Human Protein kinase C zeta type (PRKCZ) ELISA Kit

Protein kinase C, zeta is an enzyme which in humans is encoded by the PRKCZ gene. The PRKCZ gene encodes at least two alternative transcripts, the full-length PKC zeta and an N-terminal truncated form PKM zeta. The truncated PKM? is thought to be responsible for maintaining long-term memories in the brain.PKC-zeta has an N-terminal regulatory domain, followed by a hinge region and a C-terminal catalytic domain. Second messengers stimulate PKCs by binding to the regulatory domain, translocating the enzyme from cytosol to membrane, and producing a conformational change that removes autoinhibition of the PKC catalytic activity. PKM-zeta, a brain-specific isoform of PKC-zeta generated from an alternative transcript, lacks the regulatory region of full-length PKC-zeta and is therefore constitutively active.

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SPECIFICATIONS

Catalog Number

KTE61145

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

5590

Accession

Q05513

Additional Info

Human Protein kinase C zeta type (PRKCZ) ELISA Kit has high sensitivity and excellent specificity for detection of Human PRKCZ. No significant cross-reactivity or interference between Human PRKCZ and analogues was observed.