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Human Protein prune homolog (PRUNE) ELISA Kit

Cat no: KTE61098

Human Protein prune homolog (PRUNE) ELISA Kit

PRUNE, the human homologue of the Drosophila gene, is located in 1q21.3, a region highly amplified in human sarcomas, malignant tumours of mesenchymal origin. Prune protein interacts with the metastasis suppressor nm23-H1, but shows impaired affinity towards the nm23-H1 S120G mutant associated with advanced neuroblastoma.\nPrune may act as a negative regulator of nm23-H1 activity. PRUNE amplification was generally accompanied by high mRNA and moderate to high protein levels. The sarcoma samples expressed nm23-H1 mostly at low or moderate levels, whereas mRNA and protein levels were moderate to high in breast carcinomas. For the more aggressive sarcoma subtypes, 9/13 patients with PRUNE amplification developed metastases.

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SPECIFICATIONS

Catalog Number

KTE61098

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

58497

Accession

Q86TP1

Additional Info

Human Protein prune homolog (PRUNE) ELISA Kit has high sensitivity and excellent specificity for detection of Human PRUNE. No significant cross-reactivity or interference between Human PRUNE and analogues was observed.

SUPPLIER INFO

Abbkine Scientific Co.Ltd.

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