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Human Pygopus homolog 1 (PYGO1) ELISA Kit

Human Pygopus homolog 1 (PYGO1) ELISA Kit

Cat no: KTE61015

Supplier: Abbkine Scientific Co.Ltd.
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WNT signaling controls many fundamental processes during animal development. WNT transduction is mediated by the association of beta-catenin with nuclear TCF DNA-binding factors.Lgs encodes the homolog of human BCL9, and the authors provided genetic and molecular evidence that these proteins exert their function by physically linking Pygo to beta-catenin. The PYGO1 and PYGO2 proteins, which contain 419 and 406 amino acids, respectively, possess a highly conserved PHD finger that interacts with homology domain-1 (HD1) of BCL9. The findings suggested that the recruitment of PYGO permits beta-catenin to transcriptionally activate WNT target genes and raised the possibility that a deregulation of these events may play a causal role in the development of B-cell malignancies.
Catalogue number: KTE61015
Reactivities: Human
Applications: ELISA
Size: 48T, 96T, 96T*5, 96T*50
Accession: Q9Y3Y4
Gene: 26108
Additional info: Human Pygopus homolog 1 (PYGO1) ELISA Kit has high sensitivity and excellent specificity for detection of Human PYGO1. No significant cross-reactivity or interference between Human PYGO1 and analogues was observed.

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