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Human RAF proto-oncogene serine/threonine-protein kinase (RAF1) ELISA Kit

Human RAF proto-oncogene serine/threonine-protein kinase (RAF1) ELISA Kit

Cat no: KTE60981

Supplier: Abbkine Scientific Co.Ltd.
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RAF proto-oncogene serine/threonine-protein kinase (RAF1) is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in RAF1 are associated with Noonan syndrome 5 and LEOPARD syndrome 2.
Catalogue number: KTE60981
Reactivities: Human
Applications: ELISA
Size: 48T, 96T, 96T*5, 96T*50
Accession: P04049
Gene: 5894
Additional info: Human RAF proto-oncogene serine/threonine-protein kinase (RAF1) ELISA Kit has high sensitivity and excellent specificity for detection of Human RAF1. No significant cross-reactivity or interference between Human RAF1 and analogues was observed.

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