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Human Rap guanine nucleotide exchange factor 4 (RAPGEF4) ELISA Kit

Human Rap guanine nucleotide exchange factor 4 (RAPGEF4) ELISA Kit

Cat no: KTE60978

Supplier: Abbkine Scientific Co.Ltd.
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Sequence analysis predicted that the 1,011-amino acid cAMP-GEFII protein contains an N-terminal cAMP-binding domain and a C-terminal GEF domain. Expression of cAMP-GEFI and cAMP-GEFII activated RAP1A after forskolin and 3-isobutyl-1-methylxanthine stimulation, independent of the protein kinase A pathway. cAMP-GEFI and cAMP-GEFII expression did not activate or only slightly activated other RAS superfamily members after stimulation. Northern blot analysis detected expression of a 4.4-kb cAMP-GEFII transcript that was most prominent in brain and adrenal gland. Within the brain, expression was strongest in cortex, occipital pole, frontal lobe, temporal lobe, amygdala, putamen, hippocampus, and cerebellum.
Catalogue number: KTE60978
Reactivities: Human
Applications: ELISA
Size: 48T, 96T, 96T*5, 96T*50
Accession: Q8WZA2
Gene: 11069
Additional info: Human Rap guanine nucleotide exchange factor 4 (RAPGEF4) ELISA Kit has high sensitivity and excellent specificity for detection of Human RAPGEF4. No significant cross-reactivity or interference between Human RAPGEF4 and analogues was observed.

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