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Human Ras-related protein Rab-3B (RAB3B) ELISA Kit

Cat no: KTE60991

Human Ras-related protein Rab-3B (RAB3B) ELISA Kit

The mammalian RAB proteins show striking similarities to the S. cerevisiae YPT1 and SEC4 proteins, Ras-related GTP-binding proteins involved in the regulation of secretion.RAB3B protein shares 78% identity with RAB3A.\nAfter endocytosis, the PIGR-dIgA complex traverses several endosomal compartments and is exocytosed at the apical plasma membrane Rab3b localized to vesicular structures containing Pigr in canine kidney cells and that GTP-bound Rab3b interacted directly with the cytoplasmic domain of Pigr. Binding of dIgA to Pigr dissociated Rab3b, but a constitutively active Rab3b mutant maintained its interaction with Pigr in dIgA-treated cells. Furthermore, GTP-locked Rab3b inhibited dIgA-stimulated transcytosis.

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SPECIFICATIONS

Catalog Number

KTE60991

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

5865

Accession

P20337

Additional Info

Human Ras-related protein Rab-3B (RAB3B) ELISA Kit has high sensitivity and excellent specificity for detection of Human RAB3B. No significant cross-reactivity or interference between Human RAB3B and analogues was observed.

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