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Human Ras-specific guanine nucleotide-releasing factor RalGPS1 (RALGPS1) ELISA Kit

Human Ras-specific guanine nucleotide-releasing factor RalGPS1 (RALGPS1) ELISA Kit

Cat no: KTE62337

Supplier: Abbkine Scientific Co.Ltd.
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RalGPS1 is a Ral GEF that requires membrane targeting to function in vivo.RalGPS 1 is a highly specific Ral GEF. Guanine nucleotide exchange factors (GEFs) are responsible for coupling cell surface receptors to Ras protein activation. These molecules share the core catalytic domain of other Ras family GEFs but lack the catalytic non-conserved domain that is believed to contribute to Sos1 integrity. In vitro binding and in vivo nucleotide exchange assays indicate that these GEFs specifically catalyze the GTP loading of the Ral GTPase when overexpressed in 293T cells. A central proline-rich motif associated with the Src homology (SH)2/SH3-containing adapter proteins Grb2 and Nck in vivo, whereas a pleckstrin homology (PH) domain was located at the GEF C terminus.
Catalogue number: KTE62337
Reactivities: Human
Applications: ELISA
Size: 48T, 96T, 96T*5, 96T*50
Accession: Q5JS13
Gene: 9649
Additional info: Human Ras-specific guanine nucleotide-releasing factor RalGPS1 (RALGPS1) ELISA Kit has high sensitivity and excellent specificity for detection of Human RALGPS1. No significant cross-reactivity or interference between Human RALGPS1 and analogues was observed.

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