Human Receptor-type tyrosine-protein phosphatase eta (PTPRJ) ELISA Kit

is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This PTP is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 (PLCG1) and Linker for Activation of T Cells (LAT). This PTP was also found to dephosphorylate PDGF beta receptor, and may be involved in UV-induced signal transduction.

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SPECIFICATIONS

Catalog Number

KTE61047

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

5795

Accession

Q12913

Additional Info

Human Receptor-type tyrosine-protein phosphatase eta (PTPRJ) ELISA Kit has high sensitivity and excellent specificity for detection of Human PTPRJ. No significant cross-reactivity or interference between Human PTPRJ and analogues was observed.