Renal epithelial cells (REpiC) play a crucial role in renal function. Similar to most other epithelial cells, renal epithelial cells display a polarized morphology which is essential for their function. They reabsorb nearly all of the glucose and amino acids in the glomerular filtrate, while allowing other substances of no nutritional value to be excreted in the urine. HREpiC are capable of internalizing bacteria. They are also a major site of injury in a variety of congenital, metabolic, and inflammatory diseases. REpiC can produce inflammatory mediators such as cytokines and chemokines and actively participate in acute inflammatory processes by affecting and directing leukocyte chemotaxis via the production of IL-8. REpiC express IL-2R alpha and MHC class II antigens during inflammation indicating their capacity to participate in the pathogenesis of immune renal injury. To be able to study the relationship between renal epithelial cells and a variety of renal diseases, the HREpiC culture provides a useful in vitro model.
HREpiC are isolated from human kidneys. HREpiC are cryopreserved at passage one and delivered frozen. Each vial contains >5 x 10^5 cells in 1 ml volume. HREpiC are characterized by immunofluorescent method with antibodies to cytokeratin-18, -19 and vimentin. HREpiC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HREpiC are guaranteed to further expand for 15 population doublings in the condition provided by Creative Bioarray.
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