Human Serine/threonine-protein phosphatase PGAM5, mitochondrial (PGAM5) ELISA Kit

Cat no: KTE61237

Supplier: Abbkine Scientific Co.Ltd.

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Keap1 is a BTB-Kelch substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex that functions as a sensor for thiol-reactive chemopreventive compounds and oxidative stress. PGAM5, as a novel substrate for Keap1. The N terminus of the PGAM5 protein contains a conserved NXESGE motif that binds to the substrate binding pocket in the Kelch domain of Keap1, whereas the C-terminal PGAM domain binds Bcl-XL. Keap1-dependent ubiquitination of PGAM5 results in proteasome-dependent degradation of PGAM5. Quinone-induced oxidative stress and the chemopreventive agent sulforaphane inhibit Keap1-dependent ubiquitination of PGAM5. The identification of PGAM5 as a novel substrate of Keap1 suggests that Keap1 regulates both transcriptional and post-transcriptional responses of mammalian cells to oxidative stress.

Catalogue number:	KTE61237
Reactivities:	Human
Applications:	ELISA
Size:	48T, 96T, 96T5, 96T50
Accession:	Q96HS1
Gene:	192111
Additional info:	Human Serine/threonine-protein phosphatase PGAM5, mitochondrial (PGAM5) ELISA Kit has high sensitivity and excellent specificity for detection of Human PGAM5. No significant cross-reactivity or interference between Human PGAM5 and analogues was observed.

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Human Serine/threonine-protein phosphatase PGAM5, mitochondrial (PGAM5) ELISA Kit

Cat no: KTE61237

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