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Human Sialic acid-binding Ig-like lectin 8 (SIGLEC8) ELISA Kit

Human Sialic acid-binding Ig-like lectin 8 (SIGLEC8) ELISA Kit

Cat no: KTE60659

Supplier: Abbkine Scientific Co.Ltd.
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Floyd et al. (2000) identified a cDNA from an eosinophil cDNA library encoding SIGLEC8. Sequence analysis predicted that like other SIGLECs, the 431-amino acid, type 1 transmembrane protein contains a signal peptide, an N-terminal V-set domain, and 2 C2-set domains, as well as 3 potential N-linked glycosylation sites and a transmembrane region; however, SIGLEC8 has a truncated 47-residue cytoplasmic tail lacking the conserved tyrosine-based motifs. Binding analysis confirmed that SIGLEC8 binds to red blood cell sialic acids with a preference for 3-prime over 6-prime sialyllactose-conjugated polyacrylamide. FACS and immunoprecipitation analyses demonstrated SIGLEC8 expression on eosinophils but not other leukocytes as a 45- and 89-kD dimer.
Catalogue number: KTE60659
Reactivities: Human
Applications: ELISA
Size: 48T, 96T, 96T*5, 96T*50
Accession: Q9NYZ4
Gene: 27181
Additional info: Human Sialic acid-binding Ig-like lectin 8 (SIGLEC8) ELISA Kit has high sensitivity and excellent specificity for detection of Human SIGLEC8. No significant cross-reactivity or interference between Human SIGLEC8 and analogues was observed.

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