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Human Signal transducer and activator of transcription 4 (STAT4) ELISA Kit

Cat no: KTE60378


Supplier: Abbkine Scientific Co.Ltd.
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STAT4 is phosphorylated in response to interleukin-12 and is essential for IL12 signal transduction. For further information on STATs. STAT4 and STAT1, which both map to chromosome 2q32, may have arisen via a tandem gene duplication. However, STAT1 was expressed ubiquitously, whereas STAT4 was expressed in specific tissues, including spleen, heart, brain, peripheral blood cells, and testis. STAT4 expression was drastically increased in T cells following treatment with a DNA methyltransferase inhibitor. Truncation of methylation sites in the proximal regulatory elements of the STAT4 promoter markedly enhanced transcriptional activity. The N-terminal protein interaction domain (N domain) of STAT4 is required for STAT4 activation after IL12 signaling.
Catalogue number: KTE60378
Reactivities: Human
Applications: ELISA
Size: 48T, 96T, 96T*5, 96T*50
Accession: Q14765
Gene: 6775
Additional info: Human Signal transducer and activator of transcription 4 (STAT4) ELISA Kit has high sensitivity and excellent specificity for detection of Human STAT4. No significant cross-reactivity or interference between Human STAT4 and analogues was observed.

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