Human Single-strand selective monofunctional uracil DNA glycosylase (SMUG1) ELISA Kit

Cat no: KTE60565

Supplier: Abbkine Scientific Co.Ltd.

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Description
Additional Information

SMUG1 is a glycosylase that removes uracil from single- and double-stranded DNA in nuclear chromatin, thus contributing to base excision repair. The deduced 270-amino acid protein has a calculated molecular mass of about 30 kD. Human SMUG1 shares 60% identity with the Xenopus protein. Fluorescence-tagged SMUG1 localized predominantly to the nucleus of transiently transfected HeLa cells. SMUG1 showed broader substrate specificity than UNG2, and AP endonuclease had a strong stimulatory effect on SMUG1 against double-stranded uracil, apparently due to enhance dissociation of SMUG1 from AP sites in double-stranded DNA. SMUG1 accumulated within nucleoli in cultured epithelial cells, while UNG2 was excluded from nucleoli.

Catalogue number:	KTE60565
Reactivities:	Human
Applications:	ELISA
Size:	48T, 96T, 96T5, 96T50
Accession:	Q53HV7
Gene:	23583
Additional info:	Human Single-strand selective monofunctional uracil DNA glycosylase (SMUG1) ELISA Kit has high sensitivity and excellent specificity for detection of Human SMUG1. No significant cross-reactivity or interference between Human SMUG1 and analogues was observed.

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Human Single-strand selective monofunctional uracil DNA glycosylase (SMUG1) ELISA Kit

Cat no: KTE60565

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