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Human Ski-like protein (SKIL) ELISA Kit

Human Ski-like protein (SKIL) ELISA Kit

Cat no: KTE60648

Supplier: Abbkine Scientific Co.Ltd.
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The mouse Sno gene expresses 2 isoforms, SnoN and SnoN2, that are different from each other in a location downstream of the site of alternative splicing previously described in the human SNO gene. SnoN2 is missing a 138-bp coding segment present in mouse SnoN and human SNON. TGFB induces activation and nuclear translocation of SMAD2, SMAD3, and SMAD4. SMAD3 causes degradation of SnoN, allowing a SMAD2/SMAD4 complex to activate TGFB target genes. To initiate a negative feedback mechanism that permits a precise and timely regulation of TGFB signaling, TGFB also induces an increased expression of SnoN at a later stage, which in turn binds to SMAD heteromeric complexes and shuts off TGFB signaling.
Catalogue number: KTE60648
Reactivities: Human
Applications: ELISA
Size: 48T, 96T, 96T*5, 96T*50
Accession: P12757
Gene: 6498
Additional info: Human Ski-like protein (SKIL) ELISA Kit has high sensitivity and excellent specificity for detection of Human SKIL. No significant cross-reactivity or interference between Human SKIL and analogues was observed.

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