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Human Sodium/bile acid cotransporter (SLC10A1) ELISA Kit

Cat no: KTE60644

Human Sodium/bile acid cotransporter (SLC10A1) ELISA Kit

Sodium/bile acid cotransporters are integral membrane glycoproteins. Two homologous transporters are involved in the reabsorption of bile acids, one absorbing from the intestinal lumen, the bile duct, and the kidney with an apical localization (SLC10A2;), and the other being found in the basolateral membranes of hepatocytes (SLC10A1). SLC10A1 contains an exoplasmic N terminus, an odd number of transmembrane regions, and a cytoplasmic C terminus. Alanine insertion experiments confirmed that 7 of the 9 hydrophobic stretches are membrane-integrated, with secondary structures and transport activity sensitive to positional displacement. Two amphipathic sequences are critical for intramolecular interactions and for proper trafficking of SLC10A1 to the plasma membrane.

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SPECIFICATIONS

Catalog Number

KTE60644

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

6554

Accession

Q14973

Additional Info

Human Sodium/bile acid cotransporter (SLC10A1) ELISA Kit has high sensitivity and excellent specificity for detection of Human SLC10A1. No significant cross-reactivity or interference between Human SLC10A1 and analogues was observed.

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