Human Spermidine synthase (SRM) ELISA Kit

It has SH2, SH2', and SH3 domains and a tyrosine residue for autophosphorylation in the kinase domain but lacks an N-terminal glycine for myristylation and a C-terminal tyrosine which, when phosphorylated, suppresses kinase activity. These are structural features of the recently identified Tec family of nonreceptor tyrosine kinases. The Srm N-terminal unique domain, however, lacks the structural characteristics of the Tec family kinases, and the sequence similarity is highest to Src in the SH region. Mutant mice were generated by gene targeting in embryonic stem cells but displayed no apparent phenotype as in mutant mice expressing Src family kinases. These results suggest that Srm constitutes a new family of nonreceptor tyrosine kinases that may be redundant in function.

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SPECIFICATIONS

Catalog Number

KTE60360

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

6723

Accession

P19623

Additional Info

Human Spermidine synthase (SRM) ELISA Kit has high sensitivity and excellent specificity for detection of Human SRM. No significant cross-reactivity or interference between Human SRM and analogues was observed.