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Human Spindlin-1 (SPIN1) ELISA Kit

Cat no: KTE60524

Human Spindlin-1 (SPIN1) ELISA Kit

Spindlin-1 (SPIN1) is a chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes. May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption.

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SPECIFICATIONS

Catalog Number

KTE60524

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

10927

Accession

Q9Y657

Additional Info

Human Spindlin-1 (SPIN1) ELISA Kit has high sensitivity and excellent specificity for detection of Human SPIN1. No significant cross-reactivity or interference between Human SPIN1 and analogues was observed.

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