Human T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD4) ELISA Kit

TIM4 has an N-terminal IgV domain, followed by a long mucin stalk and a C-terminal cytoplasmic tail. The IgV domain contains an N-linked glycosylation site and a potential integrin-binding RGD motif, and the mucin stalk contains 38 potential O-linked glycosylation sites and a second N-linked glycosylation site near the membrane. The cytoplasmic domain of TIM4 lacks a conserved tyrosine kinase phosphorylation site found in other TIM family members.\nThe antigen recognized by the antibody was identified by expression cloning as a type I transmembrane protein called Tim4. Tim4 was expressed in Mac1+ cells in various mouse tissues, including spleen, lymph nodes, and fetal liver. Tim4 bound apoptotic cells by recognizing phosphatidylserine via its immunoglobulin domain.

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SPECIFICATIONS

Catalog Number

KTE62326

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

91937

Accession

Q96H15

Additional Info

Human T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD4) ELISA Kit has high sensitivity and excellent specificity for detection of Human TIMD4. No significant cross-reactivity or interference between Human TIMD4 and analogues was observed.