Home  >  Products  >  Human Tankyrase-1 (TNKS) ELISA Kit
Human Tankyrase-1 (TNKS) ELISA Kit

Human Tankyrase-1 (TNKS) ELISA Kit

Cat no: KTE60195

Supplier: Abbkine Scientific Co.Ltd.
Star_fadedStar_fadedStar_fadedStar_fadedStar_faded
0 reviews | Write a Review Pencil
Read More on Supplier Website
Tankyrase 1, a human telomeric poly(ADP-ribose) polymerase, was originally identified through its interaction with TRF1, a negative regulator of telomere length. Tankyrase 1 ADP-ribosylates TRF1 in vitro, and its overexpression induces telomere elongation in human cancer cells. Surprisingly, dissection of this domain reveals multiple discrete and overlapping binding sites for TRF1 and TAB182. Five well conserved ankyrin repeat clusters in tankyrase 1. Although each of the five ankyrin repeat clusters independently binds to TRF1, only three of the five bind toTAB182. These findings suggest that tankyrase 1 may act as a scaffold for large molecular mass complexes made up of multiple binding proteins. Potential roles for tankyrase 1-mediated higher order complexes at telomeres and at other subcellular sites.
Catalogue number: KTE60195
Reactivities: Human
Applications: ELISA
Size: 48T, 96T, 96T*5, 96T*50
Accession: O95271
Gene: 8658
Additional info: Human Tankyrase-1 (TNKS) ELISA Kit has high sensitivity and excellent specificity for detection of Human TNKS. No significant cross-reactivity or interference between Human TNKS and analogues was observed.

Get Quote

  • Best Price Guaranteed
  • Quick Response Time
  • Exclusive Promotions
Enquiry_down_arrow
Abbkine Scientific Co.Ltd.
Get a Quote Direct from
Abbkine Scientific Co.Ltd.

By submitting this form you agree to your details being passed to Abbkine Scientific Co.Ltd. for the purpose of generating the best quote*
See Full Product Listings >
Button_on Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave